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Cancer tissues showed weak to moderate cytoplasmic and occasional membranous staining. Rare duct carcinoma of breast and a few endometrial cancers showed strong cytoplasmic staining. Colorectal cancers showed moderate cytoplasmic and membranous staining with distinct extracellular material. Several cases of gliomas, lymphomas, prostate, lung and renal cancers were negative.
GENE INFORMATION
Gene name
MVB12B (HGNC Symbol)
Synonyms
C9orf28, FAM125B, FLJ00001
Description
Multivesicular body subunit 12B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]