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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADA

Gene description

Adenosine deaminase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Tissue enriched (duodenum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membrane and cytoplasmic expression in duodenum.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 3 antibodies.
HPA001399 , HPA023884 , CAB004307
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001399
HPA023884
CAB004307

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Generally most cancer cells were negative in essentially all cancer types. A few cases of some cancers including renal and pancreatic cancer showed weak cytoplamic or membraneous staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak cytoplasmic and membraneous staining was observed in most cases of prostate cancer and a few cases of all other cancer types.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

GENE INFORMATION

Gene name

ADA

Synonyms

Description

Adenosine deaminase (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44619522 - 44652233

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196839 (version 83.38)

Entrez gene

100

UniProt

P00813 (UniProt - Evidence at protein level)

neXtProt

NX_P00813

Antibodypedia

ADA antibodies

PROTEIN BROWSER

ADA-001
ADA-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADA-001
ENSP00000361965
ENST00000372874
P00813 [Direct mapping]
Adenosine deaminase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001821 [histamine secretion]
GO:0001829 [trophectodermal cell differentiation]
GO:0001883 [purine nucleoside binding]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0002314 [germinal center B cell differentiation]
GO:0002636 [positive regulation of germinal center formation]
GO:0002686 [negative regulation of leukocyte migration]
GO:0002906 [negative regulation of mature B cell apoptotic process]
GO:0004000 [adenosine deaminase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006154 [adenosine catabolic process]
GO:0006157 [deoxyadenosine catabolic process]
GO:0007568 [aging]
GO:0008270 [zinc ion binding]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010460 [positive regulation of heart rate]
GO:0016020 [membrane]
GO:0019239 [deaminase activity]
GO:0030054 [cell junction]
GO:0030324 [lung development]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032261 [purine nucleotide salvage]
GO:0032839 [dendrite cytoplasm]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0033197 [response to vitamin E]
GO:0033632 [regulation of cell-cell adhesion mediated by integrin]
GO:0042110 [T cell activation]
GO:0042323 [negative regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043101 [purine-containing compound salvage]
GO:0043103 [hypoxanthine salvage]
GO:0043278 [response to morphine]
GO:0044281 [small molecule metabolic process]
GO:0045187 [regulation of circadian sleep/wake cycle, sleep]
GO:0045580 [regulation of T cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046061 [dATP catabolic process]
GO:0046101 [hypoxanthine biosynthetic process]
GO:0046103 [inosine biosynthetic process]
GO:0046111 [xanthine biosynthetic process]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0048286 [lung alveolus development]
GO:0048541 [Peyer's patch development]
GO:0048566 [embryonic digestive tract development]
GO:0050728 [negative regulation of inflammatory response]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0060169 [negative regulation of adenosine receptor signaling pathway]
GO:0060205 [cytoplasmic membrane-bounded vesicle lumen]
GO:0060407 [negative regulation of penile erection]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0070256 [negative regulation of mucus secretion]
Show all
363 aa
40.8 kDa
No 0
ADA-008
ENSP00000441818
ENST00000537820
F5GWI4 [Direct mapping]
Adenosine deaminase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0019239 [deaminase activity]
GO:0043103 [hypoxanthine salvage]
Show all
339 aa
38.3 kDa
No 0

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