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LAMB3

GENERAL INFORMATION

Gene name

 LAMB3

Gene description

 Laminin, beta 3

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic or basement membrane expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA008069 , CAB078183
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil)

GENE INFORMATION

Gene name

 LAMB3 (HGNC Symbol)

Synonyms

 BM600-125kDa, kalinin-140kDa, LAMNB1, nicein-125kDa

Description

 Laminin, beta 3 (HGNC Symbol)

Entrez gene summary

 The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.2

Chromosome location (bp)

 209614870 - 209652466

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196878 (version 83.38)

Entrez gene

 3914

UniProt

 Q13751 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13751

Antibodypedia

 LAMB3 antibodies

PROTEIN BROWSER
LAMB3-001
LAMB3-002
LAMB3-003
LAMB3-004
LAMB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAMB3-001
ENSP00000348384
ENST00000356082
Q13751 [Direct mapping]
Laminin subunit beta-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
GO:0008544 [epidermis development]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0034329 [cell junction assembly]
GO:0035987 [endodermal cell differentiation]
Show all
 1172 aa
129.6 kDa 		Yes 0
LAMB3-002
ENSP00000355997
ENST00000367030
Q13751 [Direct mapping]
Laminin subunit beta-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
GO:0008544 [epidermis development]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0034329 [cell junction assembly]
GO:0035987 [endodermal cell differentiation]
Show all
 1172 aa
129.6 kDa 		Yes 0
LAMB3-003
ENSP00000388960
ENST00000415782
Q5THA1 [Direct mapping]
Laminin subunit beta-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 188 aa
21.6 kDa 		Yes 0
LAMB3-004
ENSP00000398683
ENST00000455193
X1WI29 [Direct mapping]
Laminin subunit beta-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 160 aa
17.9 kDa 		No 0
LAMB3-201
ENSP00000375778
ENST00000391911
Q13751 [Direct mapping]
Laminin subunit beta-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005610 [laminin-5 complex]
GO:0007155 [cell adhesion]
GO:0008544 [epidermis development]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0032403 [protein complex binding]
GO:0034329 [cell junction assembly]
GO:0035987 [endodermal cell differentiation]
GO:0050873 [brown fat cell differentiation]
Show all
 1172 aa
129.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.