Expression of SLC39A10 in cancer - Summary - The Human Protein Atlas

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SLC39A10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC39A10
Gene description	Solute carrier family 39 (zinc transporter), member 10
Protein class	Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (cerebral cortex, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, including thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA036512 , HPA036513
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Glioma p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036512	HPA036513

GENE INFORMATION
Gene name	SLC39A10 (HGNC Symbol)
Synonyms	DKFZp564L2123, FLJ90515, KIAA1265
Description	Solute carrier family 39 (zinc transporter), member 10 (HGNC Symbol)
Entrez gene summary	Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q32.3
Chromosome location (bp)	195575977 - 195737702
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196950 (version 83.38)
Entrez gene	57181
UniProt	Q9ULF5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULF5
Antibodypedia	SLC39A10 antibodies

PROTEIN BROWSER

SLC39A10-001	SLC39A10-002	SLC39A10-007	SLC39A10-009	SLC39A10-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A10-001 ENSP00000352655 ENST00000359634	Q9ULF5 [Direct mapping] Zinc transporter ZIP10 A0A024R3W5 [Target identity:100%; Query identity:100%] Solute carrier family 39 (Zinc transporter), member 10, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	831 aa 94.1 kDa	Yes	6
SLC39A10-002 ENSP00000386766 ENST00000409086	Q9ULF5 [Direct mapping] Zinc transporter ZIP10 A0A024R3W5 [Target identity:100%; Query identity:100%] Solute carrier family 39 (Zinc transporter), member 10, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002903 [negative regulation of B cell apoptotic process] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030890 [positive regulation of B cell proliferation] GO:0046873 [metal ion transmembrane transporter activity] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0055085 [transmembrane transport] GO:0071578 [zinc II ion transmembrane import] GO:1903615 [positive regulation of protein tyrosine phosphatase activity] Show all	831 aa 94.1 kDa	Yes	6
SLC39A10-007 ENSP00000389640 ENST00000458054	E7ENT5 [Direct mapping] Zinc transporter ZIP10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14.8 kDa	Yes	0
SLC39A10-009 ENSP00000409272 ENST00000418005	E7EV45 [Direct mapping] Zinc transporter ZIP10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15.3 kDa	Yes	0
SLC39A10-012 ENSP00000406590 ENST00000412905	C9J0F5 [Direct mapping] Zinc transporter ZIP10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.6 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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