Cell atlas - GMFB - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GMFB
Gene description	Glia maturation factor, beta
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the nuclear bodies. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002954
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the nuclear bodies. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved), Cytosol (approved)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA002954	U-2 OS	Nucleoplasm
HPA002954	U-2 OS	Cytosol
HPA002954	U-251 MG	Nucleoplasm
		Nuclear bodies
		Cytosol

GENE INFORMATION
Gene name	GMFB (HGNC Symbol)
Synonyms	GMF
Description	Glia maturation factor, beta (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q22.2
Chromosome location (bp)	54474484 - 54489196
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197045 (version 83.38)
Entrez gene	2764
UniProt	P60983 (UniProt - Evidence at protein level)
neXtProt	NX_P60983
Antibodypedia	GMFB antibodies

PROTEIN BROWSER

GMFB-001	GMFB-002	GMFB-004	GMFB-201	GMFB-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMFB-001 ENSP00000350757 ENST00000358056	P60983 [Direct mapping] Glia maturation factor beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004860 [protein kinase inhibitor activity] GO:0004871 [signal transducer activity] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0007612 [learning] GO:0007626 [locomotory behavior] GO:0008047 [enzyme activator activity] GO:0008083 [growth factor activity] GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0043085 [positive regulation of catalytic activity] GO:0071933 [Arp2/3 complex binding] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	142 aa 16.7 kDa	No	0
GMFB-002 ENSP00000452410 ENST00000554908	G3V3X4 [Direct mapping] Glia maturation factor beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0071933 [Arp2/3 complex binding] Show all	38 aa 4.5 kDa	No	0
GMFB-004 ENSP00000451920 ENST00000553333	G3V4P8 [Direct mapping] Glia maturation factor beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005622 [intracellular] GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0071933 [Arp2/3 complex binding] Show all	150 aa 17.5 kDa	No	0
GMFB-201 ENSP00000479543 ENST00000616146	P60983 [Direct mapping] Glia maturation factor beta Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004860 [protein kinase inhibitor activity] GO:0004871 [signal transducer activity] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0008047 [enzyme activator activity] GO:0008083 [growth factor activity] GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0043085 [positive regulation of catalytic activity] GO:0071933 [Arp2/3 complex binding] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	142 aa 16.7 kDa	No	0
GMFB-202 ENSP00000487065 ENST00000628554	G3V3X4 [Direct mapping] Glia maturation factor beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0071933 [Arp2/3 complex binding] Show all	38 aa 4.5 kDa	No	0