Fields »
ABOUT
HELP
BLOG
GMFB

GENERAL INFORMATION

Gene name

 GMFB

Gene description

 Glia maturation factor, beta

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA002954
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002954

GENE INFORMATION

Gene name

 GMFB (HGNC Symbol)

Synonyms

 GMF

Description

 Glia maturation factor, beta (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q22.2

Chromosome location (bp)

 54474484 - 54489196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197045 (version 83.38)

Entrez gene

 2764

UniProt

 P60983 (UniProt - Evidence at protein level)

neXtProt

 NX_P60983

Antibodypedia

 GMFB antibodies

PROTEIN BROWSER
GMFB-001
GMFB-002
GMFB-004
GMFB-201
GMFB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMFB-001
ENSP00000350757
ENST00000358056
P60983 [Direct mapping]
Glia maturation factor beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0004871 [signal transducer activity]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008047 [enzyme activator activity]
GO:0008083 [growth factor activity]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043085 [positive regulation of catalytic activity]
GO:0071933 [Arp2/3 complex binding]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 142 aa
16.7 kDa 		No 0
GMFB-002
ENSP00000452410
ENST00000554908
G3V3X4 [Direct mapping]
Glia maturation factor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
Show all
 38 aa
4.5 kDa 		No 0
GMFB-004
ENSP00000451920
ENST00000553333
G3V4P8 [Direct mapping]
Glia maturation factor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
Show all
 150 aa
17.5 kDa 		No 0
GMFB-201
ENSP00000479543
ENST00000616146
P60983 [Direct mapping]
Glia maturation factor beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0004871 [signal transducer activity]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008047 [enzyme activator activity]
GO:0008083 [growth factor activity]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043085 [positive regulation of catalytic activity]
GO:0071933 [Arp2/3 complex binding]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 142 aa
16.7 kDa 		No 0
GMFB-202
ENSP00000487065
ENST00000628554
G3V3X4 [Direct mapping]
Glia maturation factor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
Show all
 38 aa
4.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.