Expression of ARRDC1 in cancer - Summary - The Human Protein Atlas

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ARRDC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARRDC1
Gene description	Arrestin domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044345
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044345

GENE INFORMATION
Gene name	ARRDC1 (HGNC Symbol)
Synonyms	MGC40555
Description	Arrestin domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137605654 - 137615360
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197070 (version 83.38)
Entrez gene	92714
UniProt	Q8N5I2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5I2
Antibodypedia	ARRDC1 antibodies

PROTEIN BROWSER

ARRDC1-001	ARRDC1-006	ARRDC1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARRDC1-001 ENSP00000360475 ENST00000371421	Q8N5I2 [Direct mapping] Arrestin domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0070062 [extracellular exosome] Show all	433 aa 46 kDa	No	0
ARRDC1-006 ENSP00000406833 ENST00000419386	Q5T370 [Direct mapping] Arrestin domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		271 aa 29.3 kDa	No	0
ARRDC1-012 ENSP00000406247 ENST00000431925	Q5T371 [Direct mapping] Arrestin domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		177 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.