Tissue expression of PGAP1 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PGAP1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PGAP1
Gene description	Post-GPI attachment to proteins 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA069704
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION
Gene name	PGAP1 (HGNC Symbol)
Synonyms	Bst1, FLJ12377, SPG67
Description	Post-GPI attachment to proteins 1 (HGNC Symbol)
Entrez gene summary	PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	196833004 - 196927796
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197121 (version 83.38)
Entrez gene	80055
UniProt	Q75T13 (UniProt - Evidence at protein level)
neXtProt	NX_Q75T13
Antibodypedia	PGAP1 antibodies

PROTEIN BROWSER

PGAP1-001	PGAP1-003	PGAP1-005	PGAP1-006	PGAP1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAP1-001 ENSP00000346809 ENST00000354764	Q75T13 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006505 [GPI anchor metabolic process] GO:0006506 [GPI anchor biosynthetic process] GO:0006886 [intracellular protein transport] GO:0007605 [sensory perception of sound] GO:0009880 [embryonic pattern specification] GO:0009948 [anterior/posterior axis specification] GO:0015798 [myo-inositol transport] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0021871 [forebrain regionalization] GO:0042578 [phosphoric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0060322 [head development] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	922 aa 105.4 kDa	No	7
PGAP1-003 ENSP00000390555 ENST00000422444	H7BZN8 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	159 aa 18 kDa	No	3
PGAP1-005 ENSP00000387028 ENST00000409475	Q75T13 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006505 [GPI anchor metabolic process] GO:0006886 [intracellular protein transport] GO:0015798 [myo-inositol transport] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0042578 [phosphoric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	592 aa 68 kDa	No	1
PGAP1-006 ENSP00000386802 ENST00000409188	B4DYY6 [Direct mapping] GPI inositol-deacylase; cDNA FLJ51154, highly similar to Homo sapiens GPI deacylase (PGAP1), mRNA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006505 [GPI anchor metabolic process] GO:0006886 [intracellular protein transport] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	304 aa 34.4 kDa	No	0
PGAP1-011 ENSP00000363870 ENST00000374738	A6NI33 [Direct mapping] GPI inositol-deacylase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006505 [GPI anchor metabolic process] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	182 aa 21.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.