Expression of SERPINA1 in cancer - Summary

GENERAL INFORMATION
Gene name	SERPINA1
Gene description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma and expression in extracellular matrix in a majority of tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 5 antibodies. HPA000927 , HPA001292 , CAB013211 , CAB016648 , CAB073396
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and colorectal cancer (favourable).
Breast cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000927	HPA001292	CAB013211	CAB016648	CAB073396

GENE INFORMATION
Gene name	SERPINA1 (HGNC Symbol)
Synonyms	A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, PI, PI1
Description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	94376747 - 94390693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197249 (version 83.38)
Entrez gene	5265
UniProt	P01009 (UniProt - Evidence at protein level)
neXtProt	NX_P01009
Antibodypedia	SERPINA1 antibodies

PROTEIN BROWSER

SERPINA1-001	SERPINA1-002	SERPINA1-003	SERPINA1-004	SERPINA1-006	SERPINA1-007	SERPINA1-008	SERPINA1-010	SERPINA1-011	SERPINA1-015	SERPINA1-016	SERPINA1-017	SERPINA1-201	SERPINA1-202	SERPINA1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINA1-001 ENSP00000390299 ENST00000440909	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-002 ENSP00000376803 ENST00000393088	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-003 ENSP00000385960 ENST00000404814	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-004 ENSP00000376802 ENST00000393087	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-006 ENSP00000386094 ENST00000402629	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	359 aa 40.3 kDa	Yes	0
SERPINA1-007 ENSP00000452452 ENST00000557492	A0A0B4J278 [Direct mapping] Alpha-1-antitrypsin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	144 aa 15.7 kDa	Yes	0
SERPINA1-008 ENSP00000416354 ENST00000449399	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-010 ENSP00000451826 ENST00000557118	G3V4I7 [Direct mapping] Alpha-1-antitrypsin Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010951 [negative regulation of endopeptidase activity] Show all	22 aa 2.2 kDa	Yes	0
SERPINA1-011 ENSP00000451098 ENST00000556955	G3V387 [Direct mapping] Alpha-1-antitrypsin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	117 aa 12.7 kDa	Yes	0
SERPINA1-015 ENSP00000452480 ENST00000553327	G3V5R8 [Direct mapping] Alpha-1-antitrypsin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	92 aa 9.9 kDa	Yes	0
SERPINA1-016 ENSP00000450561 ENST00000554720	G3V2B9 [Direct mapping] Alpha-1-antitrypsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	105 aa 11.8 kDa	No	0
SERPINA1-017 ENSP00000452169 ENST00000556091	G3V544 [Direct mapping] Alpha-1-antitrypsin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	156 aa 17.1 kDa	Yes	0
SERPINA1-201 ENSP00000348068 ENST00000355814	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-202 ENSP00000408474 ENST00000437397	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0
SERPINA1-203 ENSP00000416066 ENST00000448921	P01009 [Direct mapping] Alpha-1-antitrypsin Short peptide from AAT E9KL23 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 44a Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006953 [acute-phase response] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0042802 [identical protein binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	418 aa 46.7 kDa	Yes	0