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SVIL

GENERAL INFORMATION

Gene name

 SVIL

Gene description

 Supervillin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA020095 , HPA020138 , CAB010878
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SVIL

Synonyms

Description

 Supervillin (HGNC Symbol)

Entrez gene summary

 This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p11.23

Chromosome location (bp)

 29457338 - 29736781

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197321 (version 83.38)

Entrez gene

 6840

UniProt

 O95425 (UniProt - Evidence at protein level)

neXtProt

 NX_O95425

Antibodypedia

 SVIL antibodies

PROTEIN BROWSER
SVIL-001
SVIL-003
SVIL-014
SVIL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SVIL-001
ENSP00000364549
ENST00000375400
O95425 [Direct mapping]
Supervillin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0007519 [skeletal muscle tissue development]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0036449 [microtubule minus-end]
GO:0043034 [costamere]
GO:0051015 [actin filament binding]
GO:0071437 [invadopodium]
Show all
 1788 aa
200.8 kDa 		No 0
SVIL-003
ENSP00000348128
ENST00000355867
O95425 [Direct mapping]
Supervillin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0007519 [skeletal muscle tissue development]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0036449 [microtubule minus-end]
GO:0043034 [costamere]
GO:0051015 [actin filament binding]
GO:0071437 [invadopodium]
Show all
 2214 aa
247.7 kDa 		No 0
SVIL-014
ENSP00000488171
ENST00000632315
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 963 aa
108.3 kDa 		No 0
SVIL-201
ENSP00000364547
ENST00000375398
O95425 [Direct mapping]
Supervillin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002102 [podosome]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007010 [cytoskeleton organization]
GO:0007519 [skeletal muscle tissue development]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0036449 [microtubule minus-end]
GO:0043034 [costamere]
GO:0051015 [actin filament binding]
GO:0071437 [invadopodium]
Show all
 2182 aa
244.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.