Cell atlas - FBXL22 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FBXL22

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	FBXL22
Gene description	F-box and leucine-rich repeat protein 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & cytosol.
RNA cell category	Cell line enhanced (SCLC-21H, MCF7)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA047624
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & cytosol.

Main location

Nucleoli (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047624	Hep G2	Cytosol
	HPA047624	MCF7	Nucleoli
	HPA047624	MCF7	Cytosol
	HPA047624	U-2 OS	Cytosol

GENE INFORMATION
Gene name	FBXL22 (HGNC Symbol)
Synonyms	Fbl22, FLJ39626
Description	F-box and leucine-rich repeat protein 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	63597353 - 63602428
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197361 (version 83.38)
Entrez gene	283807
UniProt	Q6P050 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P050
Antibodypedia	FBXL22 antibodies

PROTEIN BROWSER

FBXL22-001	FBXL22-002	FBXL22-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL22-001 ENSP00000353794 ENST00000360587	Q6P050 [Direct mapping] F-box and leucine-rich protein 22 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0030018 [Z disc] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	247 aa 27.3 kDa	No	0
FBXL22-002 ENSP00000453697 ENST00000534939	H0YMQ4 [Direct mapping] F-box and leucine-rich protein 22 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	130 aa 15.1 kDa	No	0
FBXL22-003 ENSP00000473666 ENST00000560325	R4GNI3 [Direct mapping] F-box and leucine-rich protein 22 Show all	Predicted intracellular proteins Show all		27 aa 3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.