Expression of FBXL22 in cancer - Summary - The Human Protein Atlas

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FBXL22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FBXL22
Gene description	F-box and leucine-rich repeat protein 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (MCF7, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (endometrium, seminal vesicle, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA047624 , HPA054627
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047624	HPA054627

GENE INFORMATION
Gene name	FBXL22 (HGNC Symbol)
Synonyms	Fbl22, FLJ39626
Description	F-box and leucine-rich repeat protein 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	63597353 - 63602428
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197361 (version 83.38)
Entrez gene	283807
UniProt	Q6P050 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P050
Antibodypedia	FBXL22 antibodies

PROTEIN BROWSER

FBXL22-001	FBXL22-002	FBXL22-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL22-001 ENSP00000353794 ENST00000360587	Q6P050 [Direct mapping] F-box and leucine-rich protein 22 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0030018 [Z disc] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	247 aa 27.3 kDa	No	0
FBXL22-002 ENSP00000453697 ENST00000534939	H0YMQ4 [Direct mapping] F-box and leucine-rich protein 22 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	130 aa 15.1 kDa	No	0
FBXL22-003 ENSP00000473666 ENST00000560325	R4GNI3 [Direct mapping] F-box and leucine-rich protein 22 Show all	Predicted intracellular proteins Show all		27 aa 3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.