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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HIST1H3D
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HIST1H3D

Gene description

Histone cluster 1, H3d

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

Supported based on 1 antibody.
HPA042570
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA042570

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells displayed moderate to strong nuclear positivity.

GENE INFORMATION

Gene name

HIST1H3D (HGNC Symbol)

Synonyms

H3/b, H3FB

Description

Histone cluster 1, H3d (HGNC Symbol)

Entrez gene summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Chromosome

6

Cytoband

p22.2

Chromosome location (bp)

26196840 - 26197250

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197409 (version 83.38)

Entrez gene

8351

UniProt

P68431 (UniProt - Evidence at protein level)

neXtProt

NX_P68431

Antibodypedia

HIST1H3D antibodies

PROTEIN BROWSER

HIST1H3D-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIST1H3D-001
ENSP00000366999
ENST00000356476
P68431 [Direct mapping]
Histone H3.1
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Predicted intracellular proteins
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0031047 [gene silencing by RNA]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051290 [protein heterotetramerization]
GO:0060968 [regulation of gene silencing]
GO:0070062 [extracellular exosome]
Show all
136 aa
15.4 kDa
No 0

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