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HIST1H3D

GENERAL INFORMATION

Gene name

 HIST1H3D

Gene description

 Histone cluster 1, H3d

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

 Supported based on 1 antibody.
HPA042570
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HIST1H3D (HGNC Symbol)

Synonyms

 H3/b, H3FB

Description

 Histone cluster 1, H3d (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 26196840 - 26197250

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197409 (version 83.38)

Entrez gene

 8351

UniProt

 P68431 (UniProt - Evidence at protein level)

neXtProt

 NX_P68431

Antibodypedia

 HIST1H3D antibodies

PROTEIN BROWSER
HIST1H3D-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H3D-001
ENSP00000366999
ENST00000356476
P68431 [Direct mapping]
Histone H3.1
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Predicted intracellular proteins
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GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0031047 [gene silencing by RNA]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051290 [protein heterotetramerization]
GO:0060968 [regulation of gene silencing]
GO:0070062 [extracellular exosome]
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 136 aa
15.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.