Expression of SHPK in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SHPK
Gene description	Sedoheptulokinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, most abundant in gastrointestinal tract and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA024361 , HPA064939
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA024361	HPA064939

GENE INFORMATION
Gene name	SHPK (HGNC Symbol)
Synonyms	CARKL, SHK
Description	Sedoheptulokinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	3608262 - 3636322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197417 (version 83.38)
Entrez gene	23729
UniProt	Q9UHJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHJ6
Antibodypedia	SHPK antibodies

PROTEIN BROWSER

SHPK-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHPK-001 ENSP00000225519 ENST00000225519	Q9UHJ6 [Direct mapping] Sedoheptulokinase Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0009052 [pentose-phosphate shunt, non-oxidative branch] GO:0016310 [phosphorylation] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0035963 [cellular response to interleukin-13] GO:0043030 [regulation of macrophage activation] GO:0046835 [carbohydrate phosphorylation] GO:0050277 [sedoheptulokinase activity] GO:0050727 [regulation of inflammatory response] GO:0071222 [cellular response to lipopolysaccharide] GO:0071353 [cellular response to interleukin-4] Show all	478 aa 51.5 kDa	No	0