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SHPK

GENERAL INFORMATION

Gene name

 SHPK

Gene description

 Sedoheptulokinase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, most abundant in gastrointestinal tract and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA024361 , HPA064939
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SHPK (HGNC Symbol)

Synonyms

 CARKL, SHK

Description

 Sedoheptulokinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 3608262 - 3636322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197417 (version 83.38)

Entrez gene

 23729

UniProt

 Q9UHJ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHJ6

Antibodypedia

 SHPK antibodies

PROTEIN BROWSER
SHPK-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHPK-001
ENSP00000225519
ENST00000225519
Q9UHJ6 [Direct mapping]
Sedoheptulokinase
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Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0009052 [pentose-phosphate shunt, non-oxidative branch]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0035963 [cellular response to interleukin-13]
GO:0043030 [regulation of macrophage activation]
GO:0046835 [carbohydrate phosphorylation]
GO:0050277 [sedoheptulokinase activity]
GO:0050727 [regulation of inflammatory response]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071353 [cellular response to interleukin-4]
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 478 aa
51.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.