Expression of SPN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SPN
Gene description	Sialophorin
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEL, HL-60, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (bone marrow, lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in immune cells, most abundant in bone marrow and lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA055244 , CAB002666
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), breast cancer (favourable) and melanoma (favourable).
Endometrial cancer p<0.001 Breast cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA055244	CAB002666

GENE INFORMATION
Gene name	SPN (HGNC Symbol)
Synonyms	CD43, GPL115, LSN
Description	Sialophorin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	29662979 - 29670876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197471 (version 83.38)
Entrez gene	6693
UniProt	P16150 (UniProt - Evidence at protein level)
neXtProt	NX_P16150
Antibodypedia	SPN antibodies

PROTEIN BROWSER

SPN-001	SPN-002	SPN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPN-001 ENSP00000378787 ENST00000395389	P16150 [Direct mapping] Leukosialin A0A024R629 [Target identity:100%; Query identity:100%] Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0007162 [negative regulation of cell adhesion] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process] GO:0042742 [defense response to bacterium] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	400 aa 40.3 kDa	Yes	1
SPN-002 ENSP00000412907 ENST00000436527	C9JUK7 [Direct mapping] Leukosialin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	355 aa 36 kDa	Yes	1
SPN-201 ENSP00000353238 ENST00000360121	P16150 [Direct mapping] Leukosialin A0A024R629 [Target identity:100%; Query identity:100%] Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001562 [response to protozoan] GO:0001808 [negative regulation of type IV hypersensitivity] GO:0001931 [uropod] GO:0001934 [positive regulation of protein phosphorylation] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0007162 [negative regulation of cell adhesion] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0031295 [T cell costimulation] GO:0042102 [positive regulation of T cell proliferation] GO:0042130 [negative regulation of T cell proliferation] GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process] GO:0042742 [defense response to bacterium] GO:0045060 [negative thymic T cell selection] GO:0050688 [regulation of defense response to virus] GO:0050776 [regulation of immune response] GO:0050868 [negative regulation of T cell activation] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0097190 [apoptotic signaling pathway] Show all	400 aa 40.3 kDa	Yes	1