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SPN

GENERAL INFORMATION

Gene name

 SPN

Gene description

 Sialophorin

Protein class

 CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow, lung)
GTEx:Group enriched (lung, small intestine, spleen)
FANTOM5:Tissue enhanced (lung, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective membranous expression in immune cells, most abundant in bone marrow and lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA055244 , CAB002666
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow, lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, tonsil)

GENE INFORMATION

Gene name

 SPN (HGNC Symbol)

Synonyms

 CD43, GPL115, LSN

Description

 Sialophorin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 29662979 - 29670876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197471 (version 83.38)

Entrez gene

 6693

UniProt

 P16150 (UniProt - Evidence at protein level)

neXtProt

 NX_P16150

Antibodypedia

 SPN antibodies

PROTEIN BROWSER
SPN-001
SPN-002
SPN-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPN-001
ENSP00000378787
ENST00000395389
P16150 [Direct mapping]
Leukosialin
A0A024R629 [Target identity:100%; Query identity:100%]
Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
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 400 aa
40.3 kDa 		Yes 1
SPN-002
ENSP00000412907
ENST00000436527
C9JUK7 [Direct mapping]
Leukosialin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 355 aa
36 kDa 		Yes 1
SPN-201
ENSP00000353238
ENST00000360121
P16150 [Direct mapping]
Leukosialin
A0A024R629 [Target identity:100%; Query identity:100%]
Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001562 [response to protozoan]
GO:0001808 [negative regulation of type IV hypersensitivity]
GO:0001931 [uropod]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0031295 [T cell costimulation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0045060 [negative thymic T cell selection]
GO:0050688 [regulation of defense response to virus]
GO:0050776 [regulation of immune response]
GO:0050868 [negative regulation of T cell activation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 400 aa
40.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.