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GZMM

GENERAL INFORMATION

Gene name

 GZMM

Gene description

 Granzyme M (lymphocyte met-ase 1)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 High expression in subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA015624
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 GZMM (HGNC Symbol)

Synonyms

 LMET1, MET1

Description

 Granzyme M (lymphocyte met-ase 1) (HGNC Symbol)

Entrez gene summary

 Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 544034 - 549924

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197540 (version 83.38)

Entrez gene

 3004

UniProt

 P51124 (UniProt - Evidence at protein level)

neXtProt

 NX_P51124

Antibodypedia

 GZMM antibodies

PROTEIN BROWSER
GZMM-001
GZMM-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GZMM-001
ENSP00000264553
ENST00000264553
P51124 [Direct mapping]
Granzyme M
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Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008219 [cell death]
GO:0008236 [serine-type peptidase activity]
GO:0016020 [membrane]
GO:0019835 [cytolysis]
GO:0045087 [innate immune response]
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 257 aa
27.5 kDa 		Yes 0
GZMM-002
ENSP00000476255
ENST00000592501
U3KQV5 [Direct mapping]
Granzyme M
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 218 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.