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Gene name

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In atlas

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ELANE
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  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ELANE

Gene description

Elastase, neutrophil expressed

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Group enriched (lung, spleen)
FANTOM5:Tissue enhanced (heart muscle, lung, spleen)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in a subset of bone marrow cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 2 antibodies.
HPA066836 , CAB015409
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, lung, spleen)

GENE INFORMATION

Gene name

ELANE (HGNC Symbol)

Synonyms

ELA2, HLE, HNE, NE

Description

Elastase, neutrophil expressed (HGNC Symbol)

Entrez gene summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

851014 - 856247

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197561 (version 83.38)

Entrez gene

1991

UniProt

P08246 (UniProt - Evidence at protein level)

neXtProt

NX_P08246

Antibodypedia

ELANE antibodies

PROTEIN BROWSER

ELANE-001
ELANE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ELANE-001
ENSP00000466090
ENST00000590230
P08246 [Direct mapping]
Neutrophil elastase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001878 [response to yeast]
GO:0002020 [protease binding]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006909 [phagocytosis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009411 [response to UV]
GO:0009986 [cell surface]
GO:0017053 [transcriptional repressor complex]
GO:0019955 [cytokine binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030141 [secretory granule]
GO:0030163 [protein catabolic process]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0042742 [defense response to bacterium]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045079 [negative regulation of chemokine biosynthetic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050778 [positive regulation of immune response]
GO:0050832 [defense response to fungus]
GO:0050900 [leukocyte migration]
GO:0050922 [negative regulation of chemotaxis]
GO:0070062 [extracellular exosome]
GO:0070947 [neutrophil mediated killing of fungus]
Show all
267 aa
28.5 kDa
Yes 0
ELANE-201
ENSP00000263621
ENST00000263621
P08246 [Direct mapping]
Neutrophil elastase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0002020 [protease binding]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006909 [phagocytosis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009411 [response to UV]
GO:0009986 [cell surface]
GO:0017053 [transcriptional repressor complex]
GO:0019955 [cytokine binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030141 [secretory granule]
GO:0030163 [protein catabolic process]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0042742 [defense response to bacterium]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045079 [negative regulation of chemokine biosynthetic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045416 [positive regulation of interleukin-8 biosynthetic process]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050922 [negative regulation of chemotaxis]
GO:0070062 [extracellular exosome]
Show all
267 aa
28.5 kDa
Yes 0

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