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BCO2

GENERAL INFORMATION

Gene name

 BCO2

Gene description

 Beta-carotene oxygenase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle, liver)
GTEx:Tissue enhanced (liver)
FANTOM5:Tissue enhanced (liver, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA039825 , HPA040695
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, pituitary gland)

GENE INFORMATION

Gene name

 BCO2 (HGNC Symbol)

Synonyms

 B-DIOX-II, BCDO2, FLJ34464

Description

 Beta-carotene oxygenase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 11

Cytoband

 q23.1

Chromosome location (bp)

 112175467 - 112224699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197580 (version 83.38)

Entrez gene

 83875

UniProt

 Q9BYV7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYV7

Antibodypedia

 BCO2 antibodies

PROTEIN BROWSER
BCO2-001
BCO2-003
BCO2-004
BCO2-005
BCO2-008
BCO2-009
BCO2-010
BCO2-016
BCO2-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCO2-001
ENSP00000350314
ENST00000357685
Q9BYV7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007603 [phototransduction, visible light]
GO:0016116 [carotenoid metabolic process]
GO:0016119 [carotene metabolic process]
GO:0016121 [carotene catabolic process]
GO:0016122 [xanthophyll metabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055114 [oxidation-reduction process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 579 aa
65.7 kDa 		No 0
BCO2-003
ENSP00000436615
ENST00000526088
Q9BYV7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007603 [phototransduction, visible light]
GO:0016116 [carotenoid metabolic process]
GO:0016119 [carotene metabolic process]
GO:0016121 [carotene catabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055114 [oxidation-reduction process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 539 aa
60.8 kDa 		No 0
BCO2-004
ENSP00000414843
ENST00000438022
Q9BYV7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007603 [phototransduction, visible light]
GO:0016116 [carotenoid metabolic process]
GO:0016119 [carotene metabolic process]
GO:0016121 [carotene catabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055114 [oxidation-reduction process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 545 aa
61.5 kDa 		No 0
BCO2-005
ENSP00000354338
ENST00000361053
Q9BYV7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007603 [phototransduction, visible light]
GO:0016116 [carotenoid metabolic process]
GO:0016119 [carotene metabolic process]
GO:0016121 [carotene catabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055114 [oxidation-reduction process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 506 aa
57.3 kDa 		No 0
BCO2-008
ENSP00000437053
ENST00000531169
Q9BYV7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007603 [phototransduction, visible light]
GO:0016116 [carotenoid metabolic process]
GO:0016119 [carotene metabolic process]
GO:0016121 [carotene catabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055114 [oxidation-reduction process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 545 aa
61.5 kDa 		No 0
BCO2-009
ENSP00000431802
ENST00000532593
Q9BYV7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0007603 [phototransduction, visible light]
GO:0016116 [carotenoid metabolic process]
GO:0016119 [carotene metabolic process]
GO:0016121 [carotene catabolic process]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0055114 [oxidation-reduction process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 474 aa
53.6 kDa 		No 0
BCO2-010
ENSP00000432045
ENST00000530677
H0YCN8 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 273 aa
31.3 kDa 		No 0
BCO2-016
ENSP00000431882
ENST00000525175
H0YCL7 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
8.4 kDa 		No 0
BCO2-019
ENSP00000476560
ENST00000532612
V9GYA9 [Direct mapping]
Beta,beta-carotene 9',10'-oxygenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 212 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.