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MYH6

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GENERAL INFORMATION

Gene name

 MYH6

Gene description

 Myosin, heavy chain 6, cardiac muscle, alpha

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MYH6

Synonyms

Description

 Myosin, heavy chain 6, cardiac muscle, alpha (HGNC Symbol)

Entrez gene summary

 Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Mar 2010]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23381990 - 23408277

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197616 (version 83.38)

Entrez gene

 4624

UniProt

 P13533 (UniProt - Evidence at protein level)

neXtProt

 NX_P13533

Antibodypedia

 MYH6 antibodies

PROTEIN BROWSER
MYH6-001
MYH6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH6-001
ENSP00000348634
ENST00000356287
P13533 [Direct mapping]
Myosin-6
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001701 [in utero embryonic development]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0007522 [visceral muscle development]
GO:0008016 [regulation of heart contraction]
GO:0008217 [regulation of blood pressure]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0019901 [protein kinase binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030239 [myofibril assembly]
GO:0030898 [actin-dependent ATPase activity]
GO:0032982 [myosin filament]
GO:0043462 [regulation of ATPase activity]
GO:0045214 [sarcomere organization]
GO:0046034 [ATP metabolic process]
GO:0048739 [cardiac muscle fiber development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 1939 aa
223.7 kDa 		No 0
MYH6-201
ENSP00000386041
ENST00000405093
P13533 [Direct mapping]
Myosin-6
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001701 [in utero embryonic development]
GO:0001725 [stress fiber]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0007522 [visceral muscle development]
GO:0008016 [regulation of heart contraction]
GO:0008217 [regulation of blood pressure]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0019901 [protein kinase binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030018 [Z disc]
GO:0030048 [actin filament-based movement]
GO:0030049 [muscle filament sliding]
GO:0030239 [myofibril assembly]
GO:0030509 [BMP signaling pathway]
GO:0030898 [actin-dependent ATPase activity]
GO:0032982 [myosin filament]
GO:0043462 [regulation of ATPase activity]
GO:0045214 [sarcomere organization]
GO:0046034 [ATP metabolic process]
GO:0048739 [cardiac muscle fiber development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060420 [regulation of heart growth]
Show all
 1939 aa
223.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.