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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MYH6
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MYH6

Gene description

Myosin, heavy chain 6, cardiac muscle, alpha

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enriched (NTERA-2)
HPA (normal tissue):Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA001239 , HPA001349 , CAB075723 , CAB075724 , CAB075725
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA001239
HPA001349
CAB075723
CAB075724
CAB075725

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of melanomas showed nuclear positivity. Remaining cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

GENE INFORMATION

Gene name

MYH6

Synonyms

Description

Myosin, heavy chain 6, cardiac muscle, alpha (HGNC Symbol)

Entrez gene summary

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Mar 2010]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

23381990 - 23408277

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197616 (version 83.38)

Entrez gene

4624

UniProt

P13533 (UniProt - Evidence at protein level)

neXtProt

NX_P13533

Antibodypedia

MYH6 antibodies

PROTEIN BROWSER

MYH6-001
MYH6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH6-001
ENSP00000348634
ENST00000356287
P13533 [Direct mapping]
Myosin-6
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001701 [in utero embryonic development]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0007522 [visceral muscle development]
GO:0008016 [regulation of heart contraction]
GO:0008217 [regulation of blood pressure]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0019901 [protein kinase binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030239 [myofibril assembly]
GO:0030898 [actin-dependent ATPase activity]
GO:0032982 [myosin filament]
GO:0043462 [regulation of ATPase activity]
GO:0045214 [sarcomere organization]
GO:0046034 [ATP metabolic process]
GO:0048739 [cardiac muscle fiber development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
1939 aa
223.7 kDa
No 0
MYH6-201
ENSP00000386041
ENST00000405093
P13533 [Direct mapping]
Myosin-6
Show all
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001701 [in utero embryonic development]
GO:0001725 [stress fiber]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0007522 [visceral muscle development]
GO:0008016 [regulation of heart contraction]
GO:0008217 [regulation of blood pressure]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0019901 [protein kinase binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030018 [Z disc]
GO:0030048 [actin filament-based movement]
GO:0030049 [muscle filament sliding]
GO:0030239 [myofibril assembly]
GO:0030509 [BMP signaling pathway]
GO:0030898 [actin-dependent ATPase activity]
GO:0032982 [myosin filament]
GO:0043462 [regulation of ATPase activity]
GO:0045214 [sarcomere organization]
GO:0046034 [ATP metabolic process]
GO:0048739 [cardiac muscle fiber development]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060420 [regulation of heart growth]
Show all
1939 aa
223.7 kDa
No 0

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