Cell atlas - NMB - The Human Protein Atlas

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NMB

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Plasma membrane
	Vesicles

Human cell
	Nucleoplasm
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	NMB
Gene description	Neuromedin B
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & vesicles. In addition localized to the plasma membrane.
RNA cell category	Cell line enhanced (A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Vesicles (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB019302
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & vesicles. In addition localized to the plasma membrane.

Main location

Nucleus (approved), Vesicles (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB019302	A-431	Nucleoplasm
			Vesicles
			Plasma membrane
	CAB019302	U-2 OS	Nucleus
	CAB019302	U-2 OS	Vesicles
	CAB019302	U-251 MG	Nucleoplasm
	CAB019302	U-251 MG	Vesicles

GENE INFORMATION
Gene name	NMB (HGNC Symbol)
Synonyms	MGC17211, MGC2277, MGC3936
Description	Neuromedin B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Chromosome	15
Cytoband	q25.2
Chromosome location (bp)	84655129 - 84658563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197696 (version 83.38)
Entrez gene	4828
UniProt	P08949 (UniProt - Evidence at protein level)
neXtProt	NX_P08949
Antibodypedia	NMB antibodies

PROTEIN BROWSER

NMB-001	NMB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NMB-001 ENSP00000353664 ENST00000360476	P08949 [Direct mapping] Neuromedin-B Neuromedin-B-32 Neuromedin-B Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] GO:0007267 [cell-cell signaling] Show all	121 aa 13.3 kDa	Yes	0
NMB-002 ENSP00000378089 ENST00000394588	P08949 [Direct mapping] Neuromedin-B Neuromedin-B-32 Neuromedin-B Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007218 [neuropeptide signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0031710 [neuromedin B receptor binding] GO:0042593 [glucose homeostasis] GO:0043005 [neuron projection] GO:0046887 [positive regulation of hormone secretion] GO:0046888 [negative regulation of hormone secretion] GO:0050482 [arachidonic acid secretion] Show all	154 aa 16.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.