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NMB

GENERAL INFORMATION

Gene name

 NMB

Gene description

 Neuromedin B

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A-431)
HPA (normal tissue):Tissue enhanced (adipose tissue, cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, including adipose tissue and CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB019302
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and glioma (favourable).
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB019302

GENE INFORMATION

Gene name

 NMB (HGNC Symbol)

Synonyms

 MGC17211, MGC2277, MGC3936

Description

 Neuromedin B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Chromosome

 15

Cytoband

 q25.2

Chromosome location (bp)

 84655129 - 84658563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197696 (version 83.38)

Entrez gene

 4828

UniProt

 P08949 (UniProt - Evidence at protein level)

neXtProt

 NX_P08949

Antibodypedia

 NMB antibodies

PROTEIN BROWSER
NMB-001
NMB-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NMB-001
ENSP00000353664
ENST00000360476
P08949 [Direct mapping]
Neuromedin-B Neuromedin-B-32 Neuromedin-B
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
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 121 aa
13.3 kDa 		Yes 0
NMB-002
ENSP00000378089
ENST00000394588
P08949 [Direct mapping]
Neuromedin-B Neuromedin-B-32 Neuromedin-B
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0031710 [neuromedin B receptor binding]
GO:0042593 [glucose homeostasis]
GO:0043005 [neuron projection]
GO:0046887 [positive regulation of hormone secretion]
GO:0046888 [negative regulation of hormone secretion]
GO:0050482 [arachidonic acid secretion]
Show all
 154 aa
16.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.