Cell atlas - PHF2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PHF2
Gene description	PHD finger protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nucleoli (supported)
Additional location	In addition localized to the Cytosol (supported)
Mouse	Localized to the Nucleus in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA010831
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli. In addition localized to the cytosol.

Main location

Nucleus (supported), Nucleoli (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA010831	A-431	Nucleus
		Nucleoli
		Cytosol
HPA010831	U-2 OS	Nucleus
HPA010831	U-2 OS	Nucleoli
HPA010831	U-251 MG	Nucleus
HPA010831	U-251 MG	Nucleoli

MOUSE CELLS

Main location

Nucleus

Mouse gene

ENSMUSG00000038025 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA010831	NIH 3T3	Nucleus

GENE INFORMATION
Gene name	PHF2 (HGNC Symbol)
Synonyms	CENP-35, JHDM1E, KIAA0662
Description	PHD finger protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	93576407 - 93679587
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197724 (version 83.38)
Entrez gene	5253
UniProt	O75151 (UniProt - Evidence at protein level)
neXtProt	NX_O75151
Antibodypedia	PHF2 antibodies

PROTEIN BROWSER

PHF2-001	PHF2-201	PHF2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHF2-001 ENSP00000352185 ENST00000359246	O75151 [Direct mapping] Lysine-specific demethylase PHF2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000777 [condensed chromosome kinetochore] GO:0001889 [liver development] GO:0003713 [transcription coactivator activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006482 [protein demethylation] GO:0008270 [zinc ion binding] GO:0032454 [histone demethylase activity (H3-K9 specific)] GO:0033169 [histone H3-K9 demethylation] GO:0035064 [methylated histone binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0061188 [negative regulation of chromatin silencing at rDNA] Show all	1096 aa 120.8 kDa	No	0
PHF2-201 ENSP00000364525 ENST00000375376	E7ET14 [Direct mapping] Lysine-specific demethylase PHF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	309 aa 33.2 kDa	No	0
PHF2-202 ENSP00000479936 ENST00000610682	A0A087WW48 [Direct mapping] Lysine-specific demethylase PHF2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	328 aa 35.3 kDa	No	0