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PHF2

GENERAL INFORMATION

Gene name

 PHF2

Gene description

 PHD finger protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA010831
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010831

GENE INFORMATION

Gene name

 PHF2 (HGNC Symbol)

Synonyms

 CENP-35, JHDM1E, KIAA0662

Description

 PHD finger protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 93576407 - 93679587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197724 (version 83.38)

Entrez gene

 5253

UniProt

 O75151 (UniProt - Evidence at protein level)

neXtProt

 NX_O75151

Antibodypedia

 PHF2 antibodies

PROTEIN BROWSER
PHF2-001
PHF2-201
PHF2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHF2-001
ENSP00000352185
ENST00000359246
O75151 [Direct mapping]
Lysine-specific demethylase PHF2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000777 [condensed chromosome kinetochore]
GO:0001889 [liver development]
GO:0003713 [transcription coactivator activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006482 [protein demethylation]
GO:0008270 [zinc ion binding]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0035064 [methylated histone binding]
GO:0051213 [dioxygenase activity]
GO:0055114 [oxidation-reduction process]
GO:0061188 [negative regulation of chromatin silencing at rDNA]
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 1096 aa
120.8 kDa 		No 0
PHF2-201
ENSP00000364525
ENST00000375376
E7ET14 [Direct mapping]
Lysine-specific demethylase PHF2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
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 309 aa
33.2 kDa 		No 0
PHF2-202
ENSP00000479936
ENST00000610682
A0A087WW48 [Direct mapping]
Lysine-specific demethylase PHF2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
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 328 aa
35.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.