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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PSAP
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PSAP

Gene description

Prosaposin

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins
Transporters

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA004426 , CAB004647
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA004426
CAB004647

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues displayed strong cytoplasmic staining with a granular pattern.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All malignant cells showed moderate to strong cytoplasmic granular positivity.

GENE INFORMATION

Gene name

PSAP (HGNC Symbol)

Synonyms

GLBA, SAP1

Description

Prosaposin (HGNC Symbol)

Entrez gene summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q22.1

Chromosome location (bp)

71816298 - 71851375

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197746 (version 83.38)

Entrez gene

5660

UniProt

P07602 (UniProt - Evidence at protein level)

neXtProt

NX_P07602

Antibodypedia

PSAP antibodies

PROTEIN BROWSER

PSAP-001
PSAP-005
PSAP-201
PSAP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSAP-001
ENSP00000378394
ENST00000394936
P07602 [Direct mapping]
Prosaposin Saposin-A Saposin-B-Val Saposin-B Saposin-C Saposin-D
A0A024QZQ2 [Target identity:100%; Query identity:100%]
Prosaposin (Variant Gaucher disease and variant metachromatic leukodystrophy), isoform CRA_b
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Transporters
   Transporter channels and pores
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006869 [lipid transport]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008047 [enzyme activator activity]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0030168 [platelet activation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043408 [regulation of MAPK cascade]
GO:0043410 [positive regulation of MAPK cascade]
GO:0044281 [small molecule metabolic process]
GO:0048589 [developmental growth]
GO:0060736 [prostate gland growth]
GO:0060742 [epithelial cell differentiation involved in prostate gland development]
GO:0070062 [extracellular exosome]
GO:0071310 [cellular response to organic substance]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
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524 aa
58.1 kDa
Yes 0
PSAP-005
ENSP00000488331
ENST00000633965
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
Show all
167 aa
18.7 kDa
No 0
PSAP-201
ENSP00000378392
ENST00000394934
C9JIZ6 [Direct mapping]
Prosaposin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
527 aa
58.4 kDa
Yes 0
PSAP-202
ENSP00000480857
ENST00000610929
Q5BJH1 [Direct mapping]
PSAP protein; Prosaposin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005764 [lysosome]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
Show all
240 aa
26.3 kDa
Yes 0

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