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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PSAP
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PSAP

Gene description

Prosaposin

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins
Transporters

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA004426 , CAB004647
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PSAP (HGNC Symbol)

Synonyms

GLBA, SAP1

Description

Prosaposin (HGNC Symbol)

Entrez gene summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q22.1

Chromosome location (bp)

71816298 - 71851375

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197746 (version 83.38)

Entrez gene

5660

UniProt

P07602 (UniProt - Evidence at protein level)

neXtProt

NX_P07602

Antibodypedia

PSAP antibodies

PROTEIN BROWSER

PSAP-001
PSAP-005
PSAP-201
PSAP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSAP-001
ENSP00000378394
ENST00000394936
P07602 [Direct mapping]
Prosaposin Saposin-A Saposin-B-Val Saposin-B Saposin-C Saposin-D
A0A024QZQ2 [Target identity:100%; Query identity:100%]
Prosaposin (Variant Gaucher disease and variant metachromatic leukodystrophy), isoform CRA_b
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Transporters
   Transporter channels and pores
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006869 [lipid transport]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008047 [enzyme activator activity]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0030168 [platelet activation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043408 [regulation of MAPK cascade]
GO:0043410 [positive regulation of MAPK cascade]
GO:0044281 [small molecule metabolic process]
GO:0048589 [developmental growth]
GO:0060736 [prostate gland growth]
GO:0060742 [epithelial cell differentiation involved in prostate gland development]
GO:0070062 [extracellular exosome]
GO:0071310 [cellular response to organic substance]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
Show all
524 aa
58.1 kDa
Yes 0
PSAP-005
ENSP00000488331
ENST00000633965
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
Show all
167 aa
18.7 kDa
No 0
PSAP-201
ENSP00000378392
ENST00000394934
C9JIZ6 [Direct mapping]
Prosaposin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
527 aa
58.4 kDa
Yes 0
PSAP-202
ENSP00000480857
ENST00000610929
Q5BJH1 [Direct mapping]
PSAP protein; Prosaposin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005764 [lysosome]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
Show all
240 aa
26.3 kDa
Yes 0

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