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MAP1LC3C

GENERAL INFORMATION

Gene name

 MAP1LC3C

Gene description

 Microtubule-associated protein 1 light chain 3 gamma

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, ASC TERT1, BEWO, EFO-21)
HPA (normal tissue):Tissue enhanced (breast, placenta)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MAP1LC3C (HGNC Symbol)

Synonyms

 ATG8J

Description

 Microtubule-associated protein 1 light chain 3 gamma (HGNC Symbol)

Entrez gene summary

 Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 241995490 - 241999073

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197769 (version 83.38)

Entrez gene

 440738

UniProt

 Q9BXW4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXW4

Antibodypedia

 MAP1LC3C antibodies

PROTEIN BROWSER
MAP1LC3C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP1LC3C-001
ENSP00000349785
ENST00000357246
Q9BXW4 [Direct mapping]
Microtubule-associated proteins 1A/1B light chain 3C
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Predicted intracellular proteins
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GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008017 [microtubule binding]
GO:0012505 [endomembrane system]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0031090 [organelle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0061025 [membrane fusion]
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 147 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.