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ZNF81

GENERAL INFORMATION

Gene name

 ZNF81

Gene description

 Zinc finger protein 81

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA001689
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001689

GENE INFORMATION

Gene name

 ZNF81 (HGNC Symbol)

Synonyms

 HFZ20, MRX45

Description

 Zinc finger protein 81 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause mental retardation X-linked type 45 (MRX45). [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 47836902 - 48002561

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197779 (version 83.38)

Entrez gene

 347344

UniProt

 P51508 (UniProt - Evidence at protein level)

neXtProt

 NX_P51508

Antibodypedia

 ZNF81 antibodies

PROTEIN BROWSER
ZNF81-001
ZNF81-002
ZNF81-003
ZNF81-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF81-001
ENSP00000366153
ENST00000376954
P51508 [Direct mapping]
Zinc finger protein 81
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
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GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 661 aa
76 kDa 		No 0
ZNF81-002
ENSP00000334641
ENST00000334937
B1AJV1 [Direct mapping]
Zinc finger protein 81
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
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 69 aa
7.9 kDa 		No 0
ZNF81-003
ENSP00000366149
ENST00000376950
B1AJV2 [Direct mapping]
Zinc finger protein 81
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Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 103 aa
11.5 kDa 		No 0
ZNF81-201
ENSP00000341151
ENST00000338637
P51508 [Direct mapping]
Zinc finger protein 81
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 661 aa
76 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.