Expression of SLC9A8 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC9A8
Gene description	Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues with distinct membranous expression in kidney glomeruli.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB033682
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB033682

GENE INFORMATION
Gene name	SLC9A8 (HGNC Symbol)
Synonyms	KIAA0939, NHE8
Description	Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 (HGNC Symbol)
Entrez gene summary	Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	49812713 - 49892242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197818 (version 83.38)
Entrez gene	23315
UniProt	Q9Y2E8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2E8
Antibodypedia	SLC9A8 antibodies

PROTEIN BROWSER

SLC9A8-001	SLC9A8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A8-001 ENSP00000354966 ENST00000361573	Q9Y2E8 [Direct mapping] Sodium/hydrogen exchanger 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	581 aa 65.4 kDa	No	>9
SLC9A8-201 ENSP00000416418 ENST00000417961	Q9Y2E8 [Direct mapping] Sodium/hydrogen exchanger 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0015386 [potassium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	597 aa 67.3 kDa	No	>9