Fields »
ABOUT
HELP
BLOG
SLC9A8

GENERAL INFORMATION

Gene name

 SLC9A8

Gene description

 Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8

Protein class

 Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues with distinct membranous expression in kidney glomeruli.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB033682
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC9A8 (HGNC Symbol)

Synonyms

 KIAA0939, NHE8

Description

 Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 (HGNC Symbol)

Entrez gene summary

 Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 49812713 - 49892242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197818 (version 83.38)

Entrez gene

 23315

UniProt

 Q9Y2E8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2E8

Antibodypedia

 SLC9A8 antibodies

PROTEIN BROWSER
SLC9A8-001
SLC9A8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC9A8-001
ENSP00000354966
ENST00000361573
Q9Y2E8 [Direct mapping]
Sodium/hydrogen exchanger 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 581 aa
65.4 kDa 		No >9
SLC9A8-201
ENSP00000416418
ENST00000417961
Q9Y2E8 [Direct mapping]
Sodium/hydrogen exchanger 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005794 [Golgi apparatus]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0015386 [potassium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 597 aa
67.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.