Expression of FCHSD1 in cancer - Summary

GENERAL INFORMATION
Gene name	FCHSD1
Gene description	FCH and double SH3 domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues, sometimes accompanied by membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043795
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), testis cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Testis cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043795

GENE INFORMATION
Gene name	FCHSD1 (HGNC Symbol)
Synonyms	FLJ00007
Description	FCH and double SH3 domains 1 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	141639302 - 141651419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197948 (version 83.38)
Entrez gene	89848
UniProt	Q86WN1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WN1
Antibodypedia	FCHSD1 antibodies

PROTEIN BROWSER

FCHSD1-001	FCHSD1-002	FCHSD1-005	FCHSD1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCHSD1-001 ENSP00000399259 ENST00000435817	Q86WN1 [Direct mapping] F-BAR and double SH3 domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	690 aa 76.9 kDa	No	0
FCHSD1-002 ENSP00000428776 ENST00000519800	E5RGB1 [Direct mapping] F-BAR and double SH3 domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		255 aa 28.7 kDa	No	0
FCHSD1-005 ENSP00000428677 ENST00000522783	E5RGT6 [Direct mapping] F-BAR and double SH3 domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	598 aa 66.6 kDa	No	0
FCHSD1-011 ENSP00000430448 ENST00000518499	E5RK49 [Direct mapping] F-BAR and double SH3 domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	211 aa 24.1 kDa	No	0