Cell atlas - NOL8 - The Human Protein Atlas

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NOL8

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	NOL8
Gene description	Nucleolar protein 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA062922
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli.

Main location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062922	PC-3	Nucleus
	HPA062922	PC-3	Nucleoli
	HPA062922	RH-30	Nucleoli
	HPA062922	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	NOL8 (HGNC Symbol)
Synonyms	C9orf34, FLJ20736, Nop132
Description	Nucleolar protein 8 (HGNC Symbol)
Entrez gene summary	NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	92297358 - 92325636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198000 (version 83.38)
Entrez gene	55035
UniProt	Q76FK4 (UniProt - Evidence at protein level)
neXtProt	NX_Q76FK4
Antibodypedia	NOL8 antibodies

PROTEIN BROWSER

NOL8-004	NOL8-006	NOL8-007	NOL8-008	NOL8-010	NOL8-013	NOL8-015	NOL8-018	NOL8-019	NOL8-020	NOL8-027	NOL8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL8-004 ENSP00000414112 ENST00000432670	F8WE42 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	970 aa 108.5 kDa	No	0
NOL8-006 ENSP00000401177 ENST00000442668	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1167 aa 131.6 kDa	No	0
NOL8-007 ENSP00000390143 ENST00000421075	A0A0A0MSJ1 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	258 aa 29.1 kDa	No	0
NOL8-008 ENSP00000440709 ENST00000542053	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1099 aa 123.9 kDa	No	0
NOL8-010 ENSP00000441300 ENST00000535387	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1129 aa 127.3 kDa	No	0
NOL8-013 ENSP00000412471 ENST00000433029	F5GWN9 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	413 aa 46.6 kDa	No	0
NOL8-015 ENSP00000441140 ENST00000545558	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1167 aa 131.6 kDa	No	0
NOL8-018 ENSP00000442666 ENST00000535807	F5H797 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.4 kDa	No	0
NOL8-019 ENSP00000442037 ENST00000536624	F5H8B8 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	145 aa 16.2 kDa	No	0
NOL8-020 ENSP00000388335 ENST00000411621	F5H692 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16.6 kDa	No	0
NOL8-027 ENSP00000442596 ENST00000542613	F5H7D5 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.8 kDa	No	0
NOL8-201 ENSP00000351723 ENST00000358855	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1099 aa 123.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.