Expression of NOL8 in cancer - Summary - The Human Protein Atlas

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NOL8

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOL8
Gene description	Nucleolar protein 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA044440
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044440

GENE INFORMATION
Gene name	NOL8 (HGNC Symbol)
Synonyms	C9orf34, FLJ20736, Nop132
Description	Nucleolar protein 8 (HGNC Symbol)
Entrez gene summary	NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	92297358 - 92325636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198000 (version 83.38)
Entrez gene	55035
UniProt	Q76FK4 (UniProt - Evidence at protein level)
neXtProt	NX_Q76FK4
Antibodypedia	NOL8 antibodies

PROTEIN BROWSER

NOL8-004	NOL8-006	NOL8-007	NOL8-008	NOL8-010	NOL8-013	NOL8-015	NOL8-018	NOL8-019	NOL8-020	NOL8-027	NOL8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL8-004 ENSP00000414112 ENST00000432670	F8WE42 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	970 aa 108.5 kDa	No	0
NOL8-006 ENSP00000401177 ENST00000442668	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1167 aa 131.6 kDa	No	0
NOL8-007 ENSP00000390143 ENST00000421075	A0A0A0MSJ1 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	258 aa 29.1 kDa	No	0
NOL8-008 ENSP00000440709 ENST00000542053	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1099 aa 123.9 kDa	No	0
NOL8-010 ENSP00000441300 ENST00000535387	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1129 aa 127.3 kDa	No	0
NOL8-013 ENSP00000412471 ENST00000433029	F5GWN9 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	413 aa 46.6 kDa	No	0
NOL8-015 ENSP00000441140 ENST00000545558	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1167 aa 131.6 kDa	No	0
NOL8-018 ENSP00000442666 ENST00000535807	F5H797 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.4 kDa	No	0
NOL8-019 ENSP00000442037 ENST00000536624	F5H8B8 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	145 aa 16.2 kDa	No	0
NOL8-020 ENSP00000388335 ENST00000411621	F5H692 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16.6 kDa	No	0
NOL8-027 ENSP00000442596 ENST00000542613	F5H7D5 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.8 kDa	No	0
NOL8-201 ENSP00000351723 ENST00000358855	Q76FK4 [Direct mapping] Nucleolar protein 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006364 [rRNA processing] GO:0030307 [positive regulation of cell growth] GO:0044822 [poly(A) RNA binding] Show all	1099 aa 123.9 kDa	No	0

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