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IRAK4

GENERAL INFORMATION

Gene name

 IRAK4

Gene description

 Interleukin-1 receptor-associated kinase 4

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
CAB016685 , CAB022077
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and urothelial cancer (favourable).
Endometrial cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016685
CAB022077

GENE INFORMATION

Gene name

 IRAK4 (HGNC Symbol)

Synonyms

 NY-REN-64

Description

 Interleukin-1 receptor-associated kinase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q12

Chromosome location (bp)

 43758944 - 43789543

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198001 (version 83.38)

Entrez gene

 51135

UniProt

 Q9NWZ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NWZ3

Antibodypedia

 IRAK4 antibodies

PROTEIN BROWSER
IRAK4-001
IRAK4-002
IRAK4-005
IRAK4-011
IRAK4-201
IRAK4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRAK4-001
ENSP00000479889
ENST00000613694
Q9NWZ3 [Direct mapping]
Interleukin-1 receptor-associated kinase 4
Q69FE3 [Target identity:100%; Query identity:100%]
Interleukin-1 receptor associated kinase-4; Interleukin-1 receptor-associated kinase 4; Interleukin-1 receptor-associated kinase 4 variant
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001816 [cytokine production]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002446 [neutrophil mediated immunity]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0010008 [endosome membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:1990266 [neutrophil migration]
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 460 aa
51.5 kDa 		No 0
IRAK4-002
ENSP00000446490
ENST00000551736
Q9NWZ3 [Direct mapping]
Interleukin-1 receptor-associated kinase 4
Q69FE3 [Target identity:100%; Query identity:100%]
Interleukin-1 receptor associated kinase-4; Interleukin-1 receptor-associated kinase 4; Interleukin-1 receptor-associated kinase 4 variant
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002446 [neutrophil mediated immunity]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0010008 [endosome membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:1990266 [neutrophil migration]
Show all
 460 aa
51.5 kDa 		No 0
IRAK4-005
ENSP00000408734
ENST00000440781
Q9NWZ3 [Direct mapping]
Interleukin-1 receptor-associated kinase 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002446 [neutrophil mediated immunity]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0010008 [endosome membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:1990266 [neutrophil migration]
Show all
 336 aa
37.7 kDa 		No 0
IRAK4-011
ENSP00000446571
ENST00000550616
F8VR40 [Direct mapping]
Interleukin-1 receptor-associated kinase 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
Show all
 89 aa
10.1 kDa 		No 0
IRAK4-201
ENSP00000390327
ENST00000431837
Q9NWZ3 [Direct mapping]
Interleukin-1 receptor-associated kinase 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002446 [neutrophil mediated immunity]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0010008 [endosome membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:1990266 [neutrophil migration]
Show all
 336 aa
37.7 kDa 		No 0
IRAK4-202
ENSP00000390651
ENST00000448290
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 218 aa
24.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.