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Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Strong positivity was observed in a majority of pancreatic and gastric cancer as well as several cases of colorectal, breast, prostate, ovarian and urothelial cancers. Several cases of malignant gliomas, malignant melanomas, liver and renal cancers were negative.
GENE INFORMATION
Gene name
CD2AP (HGNC Symbol)
Synonyms
CMS
Description
CD2-associated protein (HGNC Symbol)
Entrez gene summary
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]