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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CD2AP
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CD2AP

Gene description

CD2-associated protein

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA003267 , HPA003326 , CAB004352
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PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable) and urothelial cancer (favourable).
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003267
HPA003326
CAB004352

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant tissues displayed moderate to strong cytoplasmic and membranous immunoreactivity. Malignant gliomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells showed moderate cytoplasmic immunoreactivity. Embryonal carcinoma, endometrial and gastric cancers were strongly stained. Malignant gliomas were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Strong positivity was observed in a majority of pancreatic and gastric cancer as well as several cases of colorectal, breast, prostate, ovarian and urothelial cancers. Several cases of malignant gliomas, malignant melanomas, liver and renal cancers were negative.

GENE INFORMATION

Gene name

CD2AP (HGNC Symbol)

Synonyms

CMS

Description

CD2-associated protein (HGNC Symbol)

Entrez gene summary

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.3

Chromosome location (bp)

47477789 - 47627263

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198087 (version 83.38)

Entrez gene

23607

UniProt

Q9Y5K6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5K6

Antibodypedia

CD2AP antibodies

PROTEIN BROWSER

CD2AP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD2AP-001
ENSP00000352264
ENST00000359314
Q9Y5K6 [Direct mapping]
CD2-associated protein
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006461 [protein complex assembly]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007067 [mitotic nuclear division]
GO:0007165 [signal transduction]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0015629 [actin cytoskeleton]
GO:0016050 [vesicle organization]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030139 [endocytic vesicle]
GO:0031252 [cell leading edge]
GO:0031941 [filamentous actin]
GO:0032403 [protein complex binding]
GO:0032911 [negative regulation of transforming growth factor beta1 production]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043234 [protein complex]
GO:0045296 [cadherin binding]
GO:0048259 [regulation of receptor-mediated endocytosis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
639 aa
71.5 kDa
No 0

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