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MB

GENERAL INFORMATION

Gene name

 MB

Gene description

 Myoglobin

Protein class

 Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, head and neck cancer, prostate cancer)
HPA (cell line):Cell line enhanced (SK-BR-3, T-47d)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly specific cytoplasmic expression in striated muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003123 , CAB000060
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, head and neck cancer, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003123
CAB000060

GENE INFORMATION

Gene name

 MB (HGNC Symbol)

Synonyms

 PVALB

Description

 Myoglobin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 35606764 - 35637951

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198125 (version 83.38)

Entrez gene

 4151

UniProt

 P02144 (UniProt - Evidence at protein level)

neXtProt

 NX_P02144

Antibodypedia

 MB antibodies

PROTEIN BROWSER
MB-001
MB-002
MB-003
MB-004
MB-005
MB-006
MB-007
MB-008
MB-201
MB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MB-001
ENSP00000380489
ENST00000397326
P02144 [Direct mapping]
Myoglobin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0005344 [oxygen transporter activity]
GO:0007507 [heart development]
GO:0009725 [response to hormone]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0031444 [slow-twitch skeletal muscle fiber contraction]
GO:0042542 [response to hydrogen peroxide]
GO:0043353 [enucleate erythrocyte differentiation]
GO:0046872 [metal ion binding]
GO:0050873 [brown fat cell differentiation]
GO:0070062 [extracellular exosome]
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 154 aa
17.2 kDa 		No 0
MB-002
ENSP00000386060
ENST00000401702
Q8WVH6 [Direct mapping]
Myoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
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 99 aa
10.9 kDa 		No 0
MB-003
ENSP00000403351
ENST00000443033
B0QYF8 [Direct mapping]
Myoglobin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
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 143 aa
16 kDa 		No 0
MB-004
ENSP00000384239
ENST00000406324
P02144 [Direct mapping]
Myoglobin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
17.2 kDa 		No 0
MB-005
ENSP00000414243
ENST00000419229
F2Z337 [Direct mapping]
Myoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
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 77 aa
8.6 kDa 		No 0
MB-006
ENSP00000413309
ENST00000442617
B0QYF7 [Direct mapping]
Myoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
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 74 aa
8.1 kDa 		No 0
MB-007
ENSP00000397944
ENST00000451685
F2Z2F1 [Direct mapping]
Myoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
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 106 aa
11.9 kDa 		No 0
MB-008
ENSP00000389263
ENST00000447607
F2Z2F1 [Direct mapping]
Myoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
Show all
 106 aa
11.9 kDa 		No 0
MB-201
ENSP00000352835
ENST00000359787
P02144 [Direct mapping]
Myoglobin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
17.2 kDa 		No 0
MB-202
ENSP00000380491
ENST00000397328
P02144 [Direct mapping]
Myoglobin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 154 aa
17.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.