Expression of DDRGK1 in cancer - Summary - The Human Protein Atlas

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DDRGK1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DDRGK1
Gene description	DDRGK domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA013373
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA013373

GENE INFORMATION
Gene name	DDRGK1 (HGNC Symbol)
Synonyms	C20orf116, dJ1187M17.3
Description	DDRGK domain containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3190350 - 3204685
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198171 (version 83.38)
Entrez gene	65992
UniProt	Q96HY6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HY6
Antibodypedia	DDRGK1 antibodies

PROTEIN BROWSER

DDRGK1-001	DDRGK1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDRGK1-001 ENSP00000346483 ENST00000354488	Q96HY6 [Direct mapping] DDRGK domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0034976 [response to endoplasmic reticulum stress] GO:0044389 [ubiquitin-like protein ligase binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903721 [positive regulation of I-kappaB phosphorylation] GO:1990592 [protein K69-linked ufmylation] Show all	314 aa 35.6 kDa	No	0
DDRGK1-004 ENSP00000369548 ENST00000380201	A0A0A0MRX2 [Direct mapping] DDRGK domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		298 aa 33.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.