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DDRGK1

GENERAL INFORMATION

Gene name

 DDRGK1

Gene description

 DDRGK domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA013373
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDRGK1 (HGNC Symbol)

Synonyms

 C20orf116, dJ1187M17.3

Description

 DDRGK domain containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3190350 - 3204685

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198171 (version 83.38)

Entrez gene

 65992

UniProt

 Q96HY6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96HY6

Antibodypedia

 DDRGK1 antibodies

PROTEIN BROWSER
DDRGK1-001
DDRGK1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDRGK1-001
ENSP00000346483
ENST00000354488
Q96HY6 [Direct mapping]
DDRGK domain-containing protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0044389 [ubiquitin-like protein ligase binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1903721 [positive regulation of I-kappaB phosphorylation]
GO:1990592 [protein K69-linked ufmylation]
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 314 aa
35.6 kDa 		No 0
DDRGK1-004
ENSP00000369548
ENST00000380201
A0A0A0MRX2 [Direct mapping]
DDRGK domain-containing protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 298 aa
33.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.