Expression of RPS6KL1 in cancer - Summary - The Human Protein Atlas

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RPS6KL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPS6KL1
Gene description	Ribosomal protein S6 kinase-like 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA027451 , HPA027794
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027451	HPA027794

GENE INFORMATION
Gene name	RPS6KL1 (HGNC Symbol)
Synonyms	MGC11287
Description	Ribosomal protein S6 kinase-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	74903954 - 74923396
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198208 (version 83.38)
Entrez gene	83694
UniProt	Q9Y6S9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y6S9
Antibodypedia	RPS6KL1 antibodies

PROTEIN BROWSER

RPS6KL1-002	RPS6KL1-005	RPS6KL1-007	RPS6KL1-008	RPS6KL1-009	RPS6KL1-012	RPS6KL1-013	RPS6KL1-014	RPS6KL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS6KL1-002 ENSP00000452027 ENST00000555647	Q9Y6S9 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	549 aa 60 kDa	No	0
RPS6KL1-005 ENSP00000450567 ENST00000557413	Q9Y6S9 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	549 aa 60 kDa	No	0
RPS6KL1-007 ENSP00000451986 ENST00000555910	H0YJR0 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	48 aa 5.2 kDa	No	0
RPS6KL1-008 ENSP00000451795 ENST00000556848	H0YJM5 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	74 aa 8 kDa	No	0
RPS6KL1-009 ENSP00000451338 ENST00000556776	A0A0G2JL89 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	9 aa 1 kDa	No	0
RPS6KL1-012 ENSP00000450846 ENST00000553789	H0YJ58 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	157 aa 17.6 kDa	No	0
RPS6KL1-013 ENSP00000451152 ENST00000553971	H0YJB8 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	104 aa 11.6 kDa	No	0
RPS6KL1-014 ENSP00000450968 ENST00000553315	H0YJ80 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Predicted intracellular proteins Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	45 aa 4.8 kDa	No	0
RPS6KL1-201 ENSP00000346644 ENST00000354625	Q9Y6S9 [Direct mapping] Ribosomal protein S6 kinase-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0043231 [intracellular membrane-bounded organelle] Show all	549 aa 60 kDa	No	0

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The Human Protein Atlas

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