Expression of RPL23A in cancer - Summary - The Human Protein Atlas

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RPL23A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPL23A
Gene description	Ribosomal protein L23a
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051754
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051754

GENE INFORMATION
Gene name	RPL23A (HGNC Symbol)
Synonyms	L23A
Description	Ribosomal protein L23a (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	28719393 - 28724359
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198242 (version 83.38)
Entrez gene	6147
UniProt	P62750 (UniProt - Evidence at protein level)
neXtProt	NX_P62750
Antibodypedia	RPL23A antibodies

PROTEIN BROWSER

RPL23A-001	RPL23A-002	RPL23A-003	RPL23A-004	RPL23A-006	RPL23A-009	RPL23A-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPL23A-001 ENSP00000389103 ENST00000422514	P62750 [Direct mapping] 60S ribosomal protein L23a Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000027 [ribosomal large subunit assembly] GO:0000166 [nucleotide binding] GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008283 [cell proliferation] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019843 [rRNA binding] GO:0022625 [cytosolic large ribosomal subunit] GO:0031932 [TORC2 complex] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	156 aa 17.7 kDa	No	0
RPL23A-002 ENSP00000468172 ENST00000496182	K7EMA7 [Direct mapping] 60S ribosomal protein L23a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	70 aa 7.9 kDa	No	0
RPL23A-003 ENSP00000347969 ENST00000355731	H7BY10 [Direct mapping] 60S ribosomal protein L23a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	158 aa 17.7 kDa	No	0
RPL23A-004 ENSP00000468402 ENST00000394935	K7ERT8 [Direct mapping] 60S ribosomal protein L23a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	175 aa 19.6 kDa	No	0
RPL23A-006 ENSP00000466425 ENST00000472628	K7EMA7 [Direct mapping] 60S ribosomal protein L23a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	70 aa 7.9 kDa	No	0
RPL23A-009 ENSP00000378396 ENST00000394938	A8MUS3 [Direct mapping] 60S ribosomal protein L23a; Ribosomal protein L23a, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	194 aa 21.9 kDa	No	0
RPL23A-011 ENSP00000465342 ENST00000578181	K7EJV9 [Direct mapping] 60S ribosomal protein L23a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	170 aa 19.3 kDa	No	0

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