Cell atlas - HELZ - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HELZ

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Nucleoli
	Plasma membrane

Human cell
	Actin Filaments
	Nucleoli
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	HELZ
Gene description	Helicase with zinc finger
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli, plasma membrane & actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Plasma membrane (approved), Actin filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028276
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli, plasma membrane & actin filaments.

Main location

Nucleoli (approved), Plasma membrane (approved), Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028276	A-431	Nucleoli
	HPA028276	U-2 OS	Nucleoli
			Plasma membrane
			Actin filaments
	HPA028276	U-251 MG	Nucleoli
			Plasma membrane
			Actin filaments

GENE INFORMATION
Gene name	HELZ (HGNC Symbol)
Synonyms	DHRC, HUMORF5, KIAA0054
Description	Helicase with zinc finger (HGNC Symbol)
Entrez gene summary	HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	67070438 - 67245989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198265 (version 83.38)
Entrez gene	9931
UniProt	P42694 (UniProt - Evidence at protein level)
neXtProt	NX_P42694
Antibodypedia	HELZ antibodies

PROTEIN BROWSER

HELZ-001	HELZ-005	HELZ-006	HELZ-008	HELZ-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HELZ-001 ENSP00000351524 ENST00000358691	P42694 [Direct mapping] Probable helicase with zinc finger domain Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	1942 aa 219 kDa	No	0
HELZ-005 ENSP00000464512 ENST00000580168	J3QS41 [Direct mapping] Probable helicase with zinc finger domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	1943 aa 219.1 kDa	No	0
HELZ-006 ENSP00000462763 ENST00000581159	J3KT20 [Direct mapping] Probable helicase with zinc finger domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.9 kDa	No	0
HELZ-008 ENSP00000462320 ENST00000579861	J3KS59 [Direct mapping] Probable helicase with zinc finger domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.6 kDa	No	0
HELZ-011 ENSP00000464354 ENST00000578783	J3QRR8 [Direct mapping] Probable helicase with zinc finger domain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	193 aa 22.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.