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HELZ

GENERAL INFORMATION

Gene name

 HELZ

Gene description

 Helicase with zinc finger

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nucleolar or cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA028276
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028276

GENE INFORMATION

Gene name

 HELZ (HGNC Symbol)

Synonyms

 DHRC, HUMORF5, KIAA0054

Description

 Helicase with zinc finger (HGNC Symbol)

Entrez gene summary

 HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

Chromosome

 17

Cytoband

 q24.2

Chromosome location (bp)

 67070438 - 67245989

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198265 (version 83.38)

Entrez gene

 9931

UniProt

 P42694 (UniProt - Evidence at protein level)

neXtProt

 NX_P42694

Antibodypedia

 HELZ antibodies

PROTEIN BROWSER
HELZ-001
HELZ-005
HELZ-006
HELZ-008
HELZ-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HELZ-001
ENSP00000351524
ENST00000358691
P42694 [Direct mapping]
Probable helicase with zinc finger domain
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
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 1942 aa
219 kDa 		No 0
HELZ-005
ENSP00000464512
ENST00000580168
J3QS41 [Direct mapping]
Probable helicase with zinc finger domain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0046872 [metal ion binding]
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 1943 aa
219.1 kDa 		No 0
HELZ-006
ENSP00000462763
ENST00000581159
J3KT20 [Direct mapping]
Probable helicase with zinc finger domain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 104 aa
11.9 kDa 		No 0
HELZ-008
ENSP00000462320
ENST00000579861
J3KS59 [Direct mapping]
Probable helicase with zinc finger domain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 66 aa
7.6 kDa 		No 0
HELZ-011
ENSP00000464354
ENST00000578783
J3QRR8 [Direct mapping]
Probable helicase with zinc finger domain
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 193 aa
22.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.