Cell atlas - MYL4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MYL4

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MYL4
Gene description	Myosin, light chain 4, alkali; atrial, embryonic
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Group enriched (HEL, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051884
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEL, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051884	RH-30	Plasma membrane
	HPA051884	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	MYL4 (HGNC Symbol)
Synonyms	ALC1, AMLC, GT1, PRO1957
Description	Myosin, light chain 4, alkali; atrial, embryonic (HGNC Symbol)
Entrez gene summary	Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47200446 - 47223679
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198336 (version 83.38)
Entrez gene	4635
UniProt	P12829 (UniProt - Evidence at protein level)
neXtProt	NX_P12829
Antibodypedia	MYL4 antibodies

PROTEIN BROWSER

MYL4-001	MYL4-002	MYL4-003	MYL4-004	MYL4-005	MYL4-006	MYL4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL4-001 ENSP00000377096 ENST00000393450	P12829 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002026 [regulation of the force of heart contraction] GO:0003785 [actin monomer binding] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0016459 [myosin complex] GO:0030049 [muscle filament sliding] GO:0031672 [A band] GO:0032038 [myosin II heavy chain binding] GO:0032781 [positive regulation of ATPase activity] GO:0051015 [actin filament binding] GO:0060048 [cardiac muscle contraction] Show all	197 aa 21.6 kDa	No	0
MYL4-002 ENSP00000461570 ENST00000572316	P12829 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002026 [regulation of the force of heart contraction] GO:0003785 [actin monomer binding] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0016459 [myosin complex] GO:0030049 [muscle filament sliding] GO:0031672 [A band] GO:0032038 [myosin II heavy chain binding] GO:0032781 [positive regulation of ATPase activity] GO:0051015 [actin filament binding] GO:0060048 [cardiac muscle contraction] Show all	197 aa 21.6 kDa	No	0
MYL4-003 ENSP00000458907 ENST00000576874	I3L1K6 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	172 aa 18.9 kDa	No	0
MYL4-004 ENSP00000442375 ENST00000536623		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	197 aa 21.6 kDa	No	0
MYL4-005 ENSP00000461747 ENST00000572303	I3L532 [Direct mapping] Myosin light chain 4 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 19.4 kDa	No	0
MYL4-006 ENSP00000461121 ENST00000570671	I3L4B1 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	101 aa 11.2 kDa	No	0
MYL4-201 ENSP00000347055 ENST00000354968	P12829 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002026 [regulation of the force of heart contraction] GO:0003785 [actin monomer binding] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0016459 [myosin complex] GO:0030049 [muscle filament sliding] GO:0031672 [A band] GO:0032038 [myosin II heavy chain binding] GO:0032781 [positive regulation of ATPase activity] GO:0051015 [actin filament binding] GO:0060048 [cardiac muscle contraction] Show all	197 aa 21.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.