Expression of MYL4 in cancer - Summary - The Human Protein Atlas

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MYL4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MYL4
Gene description	Myosin, light chain 4, alkali; atrial, embryonic
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (testis cancer, thyroid cancer)
HPA (cell line):	Group enriched (HEL, K-562)
HPA (normal tissue):	Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in cardiac muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA046859 , HPA051884 , HPA063034
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (testis cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046859	HPA051884	HPA063034

GENE INFORMATION
Gene name	MYL4 (HGNC Symbol)
Synonyms	ALC1, AMLC, GT1, PRO1957
Description	Myosin, light chain 4, alkali; atrial, embryonic (HGNC Symbol)
Entrez gene summary	Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47200446 - 47223679
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198336 (version 83.38)
Entrez gene	4635
UniProt	P12829 (UniProt - Evidence at protein level)
neXtProt	NX_P12829
Antibodypedia	MYL4 antibodies

PROTEIN BROWSER

MYL4-001	MYL4-002	MYL4-003	MYL4-004	MYL4-005	MYL4-006	MYL4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL4-001 ENSP00000377096 ENST00000393450	P12829 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002026 [regulation of the force of heart contraction] GO:0003785 [actin monomer binding] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0016459 [myosin complex] GO:0030049 [muscle filament sliding] GO:0031672 [A band] GO:0032038 [myosin II heavy chain binding] GO:0032781 [positive regulation of ATPase activity] GO:0051015 [actin filament binding] GO:0060048 [cardiac muscle contraction] Show all	197 aa 21.6 kDa	No	0
MYL4-002 ENSP00000461570 ENST00000572316	P12829 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002026 [regulation of the force of heart contraction] GO:0003785 [actin monomer binding] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0016459 [myosin complex] GO:0030049 [muscle filament sliding] GO:0031672 [A band] GO:0032038 [myosin II heavy chain binding] GO:0032781 [positive regulation of ATPase activity] GO:0051015 [actin filament binding] GO:0060048 [cardiac muscle contraction] Show all	197 aa 21.6 kDa	No	0
MYL4-003 ENSP00000458907 ENST00000576874	I3L1K6 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	172 aa 18.9 kDa	No	0
MYL4-004 ENSP00000442375 ENST00000536623		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	197 aa 21.6 kDa	No	0
MYL4-005 ENSP00000461747 ENST00000572303	I3L532 [Direct mapping] Myosin light chain 4 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 19.4 kDa	No	0
MYL4-006 ENSP00000461121 ENST00000570671	I3L4B1 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	101 aa 11.2 kDa	No	0
MYL4-201 ENSP00000347055 ENST00000354968	P12829 [Direct mapping] Myosin light chain 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002026 [regulation of the force of heart contraction] GO:0003785 [actin monomer binding] GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0016459 [myosin complex] GO:0030049 [muscle filament sliding] GO:0031672 [A band] GO:0032038 [myosin II heavy chain binding] GO:0032781 [positive regulation of ATPase activity] GO:0051015 [actin filament binding] GO:0060048 [cardiac muscle contraction] Show all	197 aa 21.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.