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ASPH

GENERAL INFORMATION

Gene name

 ASPH

Gene description

 Aspartate beta-hydroxylase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 21
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA059303
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable), pancreatic cancer (unfavourable), lung cancer (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
Thyroid cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059303

GENE INFORMATION

Gene name

 ASPH (HGNC Symbol)

Synonyms

 BAH, CASQ2BP1, HAAH, JCTN

Description

 Aspartate beta-hydroxylase (HGNC Symbol)

Entrez gene summary

 This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]

Chromosome

 8

Cytoband

 q12.3

Chromosome location (bp)

 61500556 - 61714640

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198363 (version 83.38)

Entrez gene

 444

UniProt

 Q12797 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12797

Antibodypedia

 ASPH antibodies

PROTEIN BROWSER
«
ASPH-001
ASPH-002
ASPH-003
ASPH-004
ASPH-005
ASPH-006
ASPH-008
ASPH-009
ASPH-011
ASPH-015
ASPH-016
ASPH-018
ASPH-021
ASPH-022
ASPH-023
ASPH-024
ASPH-028
ASPH-029
ASPH-032
ASPH-201
ASPH-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASPH-001
ENSP00000348841
ENST00000356457
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 313 aa
34.6 kDa 		No 1
ASPH-002
ENSP00000368767
ENST00000379454
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0007389 [pattern specification process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018193 [peptidyl-amino acid modification]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0031647 [regulation of protein stability]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0035108 [limb morphogenesis]
GO:0042264 [peptidyl-aspartic acid hydroxylation]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060021 [palate development]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060325 [face morphogenesis]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:1901879 [regulation of protein depolymerization]
Show all
 758 aa
85.9 kDa 		No 1
ASPH-003
ENSP00000430245
ENST00000517903
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 298 aa
33.7 kDa 		No 1
ASPH-004
ENSP00000436188
ENST00000522603
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 210 aa
23.8 kDa 		No 1
ASPH-005
ENSP00000373856
ENST00000389204
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 225 aa
25.6 kDa 		No 1
ASPH-006
ENSP00000368762
ENST00000379449
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 203 aa
22 kDa 		No 1
ASPH-008
ENSP00000429286
ENST00000518068
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 270 aa
29.8 kDa 		No 1
ASPH-009
ENSP00000429160
ENST00000522835
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 256 aa
28.9 kDa 		No 1
ASPH-011
ENSP00000427823
ENST00000519234
E5RG56 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 327 aa
36.3 kDa 		No 1
ASPH-015
ENSP00000428060
ENST00000517661
G3XAN5 [Direct mapping]
Aspartate beta-hydroxylase, isoform CRA_c; Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 174 aa
19.4 kDa 		No 1
ASPH-016
ENSP00000427877
ENST00000518306
E5RG29 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 198 aa
22.2 kDa 		No 1
ASPH-018
ENSP00000429743
ENST00000517856
E5RHJ2 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 113 aa
11.8 kDa 		No 1
ASPH-021
ENSP00000483443
ENST00000519678
A0A087X0J4 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
 134 aa
15.4 kDa 		No 0
ASPH-022
ENSP00000479830
ENST00000519264
A0A087WW05 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 44 aa
5.1 kDa 		No 0
ASPH-023
ENSP00000430516
ENST00000522919
E5RJL3 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
 163 aa
18.7 kDa 		No 0
ASPH-024
ENSP00000429718
ENST00000522349
E5RHK2 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 136 aa
15.3 kDa 		No 1
ASPH-028
ENSP00000479945
ENST00000524173
A0A087WW51 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016020 [membrane]
Show all
 196 aa
22.7 kDa 		No 0
ASPH-029
ENSP00000478706
ENST00000523927
A0A087WUJ2 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
Show all
 186 aa
21.2 kDa 		No 0
ASPH-032
ENSP00000429954
ENST00000517847
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 299 aa
33.8 kDa 		No 1
ASPH-201
ENSP00000394013
ENST00000445642
A0A0A0MSK8 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 294 aa
32.4 kDa 		No 1
ASPH-202
ENSP00000437864
ENST00000541428
Q12797 [Direct mapping]
Aspartyl/asparaginyl beta-hydroxylase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004597 [peptide-aspartate beta-dioxygenase activity]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0009055 [electron carrier activity]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018193 [peptidyl-amino acid modification]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031585 [regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity]
GO:0032237 [activation of store-operated calcium channel activity]
GO:0032541 [cortical endoplasmic reticulum]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0033018 [sarcoplasmic reticulum lumen]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045862 [positive regulation of proteolysis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0055085 [transmembrane transport]
GO:0055114 [oxidation-reduction process]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060316 [positive regulation of ryanodine-sensitive calcium-release channel activity]
GO:0070588 [calcium ion transmembrane transport]
GO:0071277 [cellular response to calcium ion]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0097202 [activation of cysteine-type endopeptidase activity]
Show all
 729 aa
83.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.