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NTRK1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NTRK1

Gene description

Neurotrophic tyrosine kinase, receptor, type 1

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Mixed
FANTOM5:Tissue enhanced (caudate)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including neuronal cells in CNS.

DATA RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Approved based on 2 antibodies.
HPA035799 , CAB004606
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

NTRK1 (HGNC Symbol)

Synonyms

MTC, TRK, TRKA

Description

Neurotrophic tyrosine kinase, receptor, type 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.1

Chromosome location (bp)

156815640 - 156881850

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198400 (version 83.38)

Entrez gene

4914

UniProt

P04629 (UniProt - Evidence at protein level)

neXtProt

NX_P04629

Antibodypedia

NTRK1 antibodies

PROTEIN BROWSER

NTRK1-001
NTRK1-004
NTRK1-006
NTRK1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NTRK1-001
ENSP00000357179
ENST00000368196
P04629 [Direct mapping]
High affinity nerve growth factor receptor
X5DR71 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0010465 [nerve growth factor receptor activity]
GO:0010623 [developmental programmed cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0042803 [protein homodimerization activity]
GO:0043068 [positive regulation of programmed cell death]
GO:0043121 [neurotrophin binding]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048406 [nerve growth factor binding]
GO:0048485 [sympathetic nervous system development]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
790 aa
86.9 kDa
Yes 1
NTRK1-004
ENSP00000376120
ENST00000392302
P04629 [Direct mapping]
High affinity nerve growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0010465 [nerve growth factor receptor activity]
GO:0010623 [developmental programmed cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0042803 [protein homodimerization activity]
GO:0043068 [positive regulation of programmed cell death]
GO:0043121 [neurotrophin binding]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048406 [nerve growth factor binding]
GO:0048485 [sympathetic nervous system development]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
760 aa
84 kDa
Yes 1
NTRK1-006
ENSP00000351486
ENST00000358660
J3KP20 [Direct mapping]
Tyrosine-protein kinase receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005030 [neurotrophin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038179 [neurotrophin signaling pathway]
Show all
793 aa
87.1 kDa
Yes 1
NTRK1-007
ENSP00000431418
ENST00000524377
P04629 [Direct mapping]
High affinity nerve growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007568 [aging]
GO:0007611 [learning or memory]
GO:0007623 [circadian rhythm]
GO:0008285 [negative regulation of cell proliferation]
GO:0009314 [response to radiation]
GO:0009986 [cell surface]
GO:0010465 [nerve growth factor receptor activity]
GO:0010623 [developmental programmed cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019233 [sensory perception of pain]
GO:0019900 [kinase binding]
GO:0021553 [olfactory nerve development]
GO:0030183 [B cell differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031410 [cytoplasmic vesicle]
GO:0031667 [response to nutrient levels]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0035094 [response to nicotine]
GO:0038180 [nerve growth factor signaling pathway]
GO:0042490 [mechanoreceptor differentiation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043068 [positive regulation of programmed cell death]
GO:0043121 [neurotrophin binding]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045471 [response to ethanol]
GO:0045766 [positive regulation of angiogenesis]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048406 [nerve growth factor binding]
GO:0048485 [sympathetic nervous system development]
GO:0048678 [response to axon injury]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051599 [response to hydrostatic pressure]
GO:0051602 [response to electrical stimulus]
GO:0051965 [positive regulation of synapse assembly]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060009 [Sertoli cell development]
GO:0060384 [innervation]
GO:0060385 [axonogenesis involved in innervation]
GO:0061368 [behavioral response to formalin induced pain]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071316 [cellular response to nicotine]
GO:0071363 [cellular response to growth factor stimulus]
GO:1901215 [negative regulation of neuron death]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
796 aa
87.5 kDa
Yes 1

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