Cell atlas - MGEA5 - The Human Protein Atlas

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MGEA5

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MGEA5
Gene description	Meningioma expressed antigen 5 (hyaluronidase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA076501
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA076501	A-431	Cytosol
	HPA076501	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MGEA5 (HGNC Symbol)
Synonyms	MEA5, NCOAT, OGA
Description	Meningioma expressed antigen 5 (hyaluronidase) (HGNC Symbol)
Entrez gene summary	The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	101784443 - 101818465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198408 (version 83.38)
Entrez gene	10724
UniProt	O60502 (UniProt - Evidence at protein level)
neXtProt	NX_O60502
Antibodypedia	MGEA5 antibodies

PROTEIN BROWSER

MGEA5-002	MGEA5-003	MGEA5-004	MGEA5-005	MGEA5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGEA5-002 ENSP00000414235 ENST00000429860	H7C3X0 [Direct mapping] Protein O-GlcNAcase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29.7 kDa	No	0
MGEA5-003 ENSP00000354850 ENST00000361464	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	916 aa 102.9 kDa	No	0
MGEA5-004 ENSP00000350445 ENST00000357797	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	849 aa 95.3 kDa	No	0
MGEA5-005 ENSP00000359112 ENST00000370094	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	677 aa 76.2 kDa	No	0
MGEA5-201 ENSP00000409973 ENST00000439817	O60502 [Direct mapping] Protein O-GlcNAcase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004415 [hyalurononglucosaminidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006516 [glycoprotein catabolic process] GO:0006517 [protein deglycosylation] GO:0016020 [membrane] GO:0016231 [beta-N-acetylglucosaminidase activity] Show all	863 aa 96.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.